Medroxyprogesterone injection [Contraceptive]

What is this medicine?

MEDROXYPROGESTERONE (me DROX ee proe JES te rone) contraceptive injections prevent pregnancy. They provide effective birth control for 3 months. Depo-SubQ Provera 104 injection is also used for treating pain related to endometriosis.

How should I use this medicine?

Depo-Provera CI contraceptive injection is given into a muscle. Depo-subQ Provera 104 injection is given under the skin. It is given by a health care provider in a hospital or clinic setting. The injection is usually given during the first 5 days after the start of a menstrual period or 6 weeks after delivery of a baby.

A patient package insert for the product will be given with each prescription and refill. Be sure to read this information carefully each time. The sheet may change often.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. These injections have been used in female children who have started having menstrual periods.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • blood clot (chest pain; shortness of breath; pain, swelling, or warmth in the leg)

  • breast tenderness or discharge

  • changes in emotions or moods

  • changes in vision

  • liver injury (dark yellow or brown urine; general ill feeling or flu-like symptoms; loss of appetite, right upper belly pain; unusually weak or tired, yellowing of the eyes or skin)

  • persistent pain, pus, or bleeding at the injection site

  • stroke (changes in vision; confusion; trouble speaking or understanding; severe headaches; sudden numbness or weakness of the face, arm or leg; trouble walking; dizziness; loss of balance or coordination)

  • trouble breathing

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • change in sex drive

  • dizziness

  • fluid retention

  • headache

  • irregular periods, spotting, or absent periods

  • pain, redness, or irritation at site where injected

  • stomach pain

  • weight gain

What may interact with this medicine?

  • antibiotics or medicines for infections, especially rifampin and griseofulvin

  • antivirals for HIV or hepatitis

  • aprepitant

  • armodafinil

  • bexarotene

  • bosentan

  • medicines for seizures like carbamazepine, felbamate, oxcarbazepine, phenytoin, phenobarbital, primidone, topiramate

  • mitotane

  • modafinil

  • St. John's wort

What if I miss a dose?

Keep appointments for follow-up doses. You must get an injection once every 3 months. It is important not to miss your dose. Call your health care provider if you are unable to keep an appointment.

Where should I keep my medicine?

This injection is only given by a health care provider. It will not be stored at home.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • asthma

  • blood clots

  • breast cancer or family history of breast cancer

  • depression

  • diabetes

  • eating disorder (anorexia nervosa)

  • heart attack

  • high blood pressure

  • HIV infection or AIDS

  • if you often drink alcohol

  • kidney disease

  • liver disease

  • migraine headaches

  • osteoporosis, weak bones

  • seizures

  • stroke

  • tobacco smoker

  • vaginal bleeding

  • an unusual or allergic reaction to medroxyprogesterone, other hormones, medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

What should I watch for while using this medicine?

This drug does not protect you against HIV infection (AIDS) or other sexually transmitted diseases.

Use of this product may cause you to lose calcium from your bones. Loss of calcium may cause weak bones (osteoporosis). Only use this product for more than 2 years if other forms of birth control are not right for you. The longer you use this product for birth control the more likely you will be at risk for weak bones. Ask your health care professional how you can keep strong bones.

You may have a change in bleeding pattern or irregular periods. Many females stop having periods while taking this drug.

If you have received your injections on time, your chance of being pregnant is very low. If you think you may be pregnant, see your health care professional as soon as possible.

Tell your health care professional if you want to get pregnant within the next year. The effect of this medicine may last a long time after you get your last injection.

NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Copyright© 2021 Elsevier